資訊中心NEWS CENTER
在發(fā)展中求生存，不斷完善，以良好信譽(yù)和科學(xué)的管理促進(jìn)企業(yè)迅速發(fā)展INTRODUCTION
VIP （vasoactive intestinal peptide）, a peptide hormone, has been implicated in a number of biological processes including: increasing digestive system motility, stimulating pepsinogen secretion, controlling the mammalian circadian timekeeping machinery, regulating prolactin secretion, and causing vasodilation. One problem with synthesis of VIP is aspartimide formation during Fmoc deprotection. Aspartimide formation occurs most frequently in peptides containing Asp followed by Asn（Trt）, Gly, Thr, or Ser. The use of 5% piperazine with 0.1 M HOBt for the deprotection solution can readily reduce the amount of aspartimide formation during microwave peptide synthesis providing the VIP peptide in high crude purity compared to the conventional method.
Figure 1: Aspartimide Formation
SCROLL
聯(lián)系人：高
座機(jī)：010-65528800
地址：北京市朝陽(yáng)區(qū)吉慶里14號(hào)佳匯國(guó)際A202室
快速導(dǎo)航
產(chǎn)品系列
產(chǎn)品推薦
Copyright©2025 培安有限公司 版權(quán)所有 All Rights Reserved 備案號(hào)：京ICP備17026558號(hào)-1 總訪問(wèn)量：481413
技術(shù)支持：化工儀器網(wǎng) 管理登錄 sitemap.xml
手機(jī)：010-65528800